Survival Following Mastectomy vs Breast-Conserving Surgery Plus Radiotherapy

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 The following article is a component of conference coverage from the 17th St. Gallen International carcinoma Symposium, which is being held virtually from March 7-21, 2021. The team at Cancer Therapy Advisor is going to be reporting on the newest research conducted by leading experts in carcinoma. Check back for more from the 17th St. Gallen International carcinoma Symposium.


Women with carcinoma who underwent breast-conserving surgery with postoperative radiotherapy were found to possess better survival than those that received a mastectomy, no matter radiotherapy, consistent with the results of a Swedish study presented at the 17th St. Gallen International carcinoma Conference 2021.

These results indicate that “when both interventions are valid options for the individual patient, mastectomy shouldn't be considered adequate to breast conservation,” consistent with Jana de Boniface, MD, Ph.D., of Karolinska Institute, Stockholm, Sweden, and colleagues.

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According to the poster presentation, recent studies indicated that breast-conserving surgery with radiotherapy resulted in better survival than mastectomy without radiotherapy; however, the info didn't indicate if this was an independent effect or a consequence of selection bias.

To explore this further, the researchers conducted a prospective study that included 48,986 women from national registries in Sweden. All of the ladies were diagnosed with primary invasive T1-2 N0-2 carcinoma between 2008 and 2017. Treatments included breast-conserving surgery plus radiotherapy (59.9%), mastectomy without radiotherapy (25.3%), or mastectomy with radiotherapy (14.7%).

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The investigators presented their results after a median follow-up of 6.28 years. the general 5-year survival was 91.1%, with a 5-year breast cancer-specific survival of 96.3%.

The data were adjusted for all pivotal confounders of comorbidity and socioeconomic status including age, civil year, residence, grade, TNM (tumor, node, metastasis) classification, subtype, education, family income, and country of birth.

After these adjustments, overall survival and breast cancer-specific survival were found to be significantly worse for ladies who underwent mastectomy without radiotherapy (hazard ratio [HR] 1.79; 95% CI, 1.66-1.92 and HR 1.66; 95% CI, 1.45-1.90) and mastectomy plus radiotherapy (HR 1.24; 95% CI, 1.13-1.37 and HR 1.26; 95% CI, 1.08-1.46) compared with breast-conserving surgery plus radiotherapy.

Visit Cancer Therapy Advisor’s conference section for more coverage of the 17th St. Gallen International carcinoma Symposium.

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