Predicting long term outcomes for pre-invasive breast cancer

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 New research has presented a replacement and more accurate method of predicting long-term outcomes for ductal carcinoma and has confirmed the role of the estrogen receptor biomarker during this sort of pre-invasive carcinoma.


Oestrogen receptor (ER), a kind of protein that's expressed in some carcinoma cells, is routinely tested in invasive carcinoma to predict long-term outcomes and choose treatment options, however, its role in ductal carcinoma in place (DCIS) has been previously unclear. However, this new research confirms the role of ER in predicting long-term outcomes in DCIS.

In the study by the Queen Mary University of London, published in Clinical Cancer Research, the authors report a replacement and more accurate method to gauge ER for predicting long-term outcomes in DCIS.

Oestrogen receptor

ER isn't generally evaluated during this pre-invasive stage of carcinoma and this study is that the first to use samples to research ER as a prognostic marker in DCIS.

The researchers observed multi-clonality in ER expression in 11% of ER-positive DCIS (ie: ER-positive DCIS with distinct ER-negative clones) and investigated the prognostic role of such multi-clonality in ER expression, finding that ER may be a strong prognostic factor with greater than three-fold risk of ipsilateral recurrence in ER-negative DCIS.

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Lead author Mangesh Thorat, Queen Mary University of London, said: “It is unlikely that such a study could currently be reproduced elsewhere within the world, and therefore the robustness of those results means we will believe them to form changes to clinical practice. Routine testing of ER in DCIS will help to avoid both overtreatment and undertreatment during this sort of carcinoma. The insights from this study also will help improve future carcinoma research through the utilization of latest scientific models, particularly in areas of drug resistance and therefore the use of targeted therapies.”

Michelle Mitchell, chief executive of Cancer Research UK which contributed to the funding of the study, said: “It’s currently very difficult to work out whether DCIS will become invasive carcinoma, meaning thousands of individuals undergo unnecessary and intense treatment. This research shows that within the future we'd be ready to confirm patients are becoming the proper care, potentially saving many from undergoing cancer treatment that's both physically and mentally demanding.”

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