Gamma oryzanol can prevent cytokine storm in Covid patients: Experts

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 New Delhi: Using gamma oryzanol a strong antioxidant in supplement form on Covid-19 patients with obesity can significantly prevent cytokine storm in them and thereby safeguard them from negative clinical outcomes, health experts said on Sunday.


The findings suggest that rice bran supplement containing natural compounds as gamma oryzanol are often considered a coadjutant therapy to stop the cytokine storm in Covid-19 patients with obesity conditions.

“Gamma-oryzanol has anti-inflammatory and antioxidant properties and thanks to which it's the potential to assist prevent negative clinical outcomes in such patients who have inflammatory tendencies,” Neha Gupta, Infectious Diseases specialist, Medanta – The Medicity told IANS.

Cytokine storm is an umbrella term encompassing several disorders of immune dysregulation and multiorgan dysfunction which will cause multiorgan failure if inadequately treated.

The main reason for a better prevalence of negative clinical outcomes thanks to Covid-19 in obese individuals is thanks to the cytokine storm, which ends up from the cytokine production from both obesity and virus infection.

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“Its consumption helps reduce inflammation within the body and if accidentally that person catches Covid-19, complications in such one that is already using anti-inflammatory and antioxidant compound i.e. gamma oryzanol are going to be very less severe and therefore the chance of cytokine storm are going to be prevented by the body’s own system,” said S P Byotra, Chairman of Department of drugs, Sir Ganga Ram Hospital, New Delhi.

In a meta-analysis, published within the journal Obesity Reviews, a team of researchers pooled data of 399,000 patients and located that folks with obesity who contracted SARS-CoV-2 were 113 percent more likely than people of healthy weight to land within the hospital, 74 percent more likely to be admitted to an ICU, and 48 percent more likely to die.

According to the experts, people with obesity are more likely than normal-weight people to possess other diseases that are independent risk factors for severe Covid-19, including heart condition, lung disease, and diabetes.

They are also susceptible to metabolic syndrome, during which blood glucose levels, fat levels, or both are unhealthy and vital signs could also be high.

“In Covid-19, patients might develop a hyperinflammatory condition and therefore the cytokine storm syndrome, which may cause organ dysfunctions and failure, and even, death. Very recently, a study conducted confirmed that Gamma Oryzanol may be a potential therapeutic adjuvant to avoid or attenuate the cytokine storm in Covid-19 patients,” said Gupta.

A recent study from Tulane University of 287 hospitalized Covid-19 patients found that metabolic syndrome itself substantially increased the risks of ICU admission, ventilation, and death.

Studies have also shown that gamma-oryzanol features a positive action within the treatment of some obesity-related comorbidities and attenuation of proinflammatory cytokines.

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