''Energy deficiency in brain cells may up Parkinson''s risk''

-

(MENAFN - IANS)

Chennai, March 10 (IANS) A team of researchers at the Indian Institute of Technology (IIT) Madras has found energy deficiency in certain cells within the human brain to be a serious cause for paralysis agitans, a neurodegenerative disorder.




According to the team, it's known that paralysis agitans is caused by the loss of dopaminergic cells (located within the central nervous system) in the nucleus niger pars compacta (SNc), a key component of the ventral midbrain.

"It is sort of remarkable that loss of neurons during a small nucleus like SNc can have wide-ranging, devastating effects altogether the four major domains of brain function -- sensory-motor, cognitive, affective and autonomous," V. Srinivasa Chakravarthy from the institution said during a statement.

"The sequence of the three computational studies suggests that metabolic deficiency within the basal ganglia circuit is that the common underlying factor at the subcellular, cellular and network-level in paralysis agitans. Thus, we have a fairly comprehensive theory of the pathogenesis of paralysis agitans," Chakravarthy added.


For the study, published within the International Journal of Scientific Reports, the team developed a computational model that showed that energy deficiency could be a serious explanation for SNc cell loss in paralysis agitans.

At the subcellular level, metabolic deficiency results in changes including alpha-synuclein aggregation, reactive oxygen species production, calcium elevation, and dopamine dysfunction, which are characteristic subcellular changes in paralysis agitans, the study indicated.

This research aims to create a simplified model of the entire brain and use it to develop applications in medicine and engineering, the team said.

Parkinson's disease is that the second most prominent neurodegenerative disease around the globe after Alzheimer's disease.

Legal Disclaimer:
MENAFN provides the knowledge “as is” without warranty of any kind. We don't accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the knowledge contained during this article. If you've got any complaints or copyright issues associated with this text, kindly contact the provider above.

Comments

Post a Comment

Popular posts from this blog

Brazil coronavirus variant found in Nevada

-
Image
 Three cases of a coronavirus variant first identified in Brazil and thought to be more easily transmissible are found in Nevada, a minimum of one among them in Clark County. The first case within the state of the variant referred to as P.1 was detected in Clark County late last month, said Mark Pandori, director of the Nevada State Public Health Laboratory at the varsity of drugs at the University of Nevada, Reno. Two more cases were found in the week by the Centers for Disease Control and Prevention in samples of positive COVID-19 tests provided by private labs. Information on these cases, like the counties where they originated, wasn't immediately available. Representatives of the Southern Nevada Health District didn't answer an invitation for comment late Friday afternoon. The Washoe County Health Department, the general public health agency for Nevada’s most populous county in Northern Nevada, has not reported any cases of the Brazilian variant, representative Scott Oxarar...
Read more

St. Barts orders vaccination campaign to reopen borders

-
Image
 Beginning April 19, 2021, the French Government will launch a vaccination campaign to immunize all eligible adults on the island. it's anticipated that the campaign will last 2 to three weeks. Saint Barthelemy has set a goal to reopen its borders by the center of May of this year. The Centers for Disease Control and Prevention (CDC) presently ranks the island of St. Barts with the very best level of a travel warning. Borders on the island of St. Bart are pack up since February 3, 2021. The goal is to reopen St. Barts’ borders by mid-May. Currently, the Centers for Disease Control and Prevention (CDC) rates the COVID-19 level in Saint Barthelemy as Very High (level 4), the very best warning level. As of February 3, 2021, the French Government enacted preventive measures against COVID-19 “variants” to all or any or any overseas territories which entail the temporary closing of borders to all visitors (St. Barts residents, no matter their nationality, aren't included). The CDC we...
Read more